ADGRE1

Across TCGA patient cohorts, ADGRE1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRE1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and 4E-BP1. Each is linked with ADGRE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRE1-to-partner and partner-to-ADGRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADGRE1-low versus ADGRE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE1→partner) and Y-score (partner→ADGRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.595	+2.189	<.001	.001	3	5
UCEC	eIF4E →	+0.182	+3.820	.003	<.001	3	3
UCEC	4E-BP1 →	+0.337	+3.247	<.001	<.001	3	3
SKCM	Src_pY416 →	+0.244	+1.678	.006	.018	3	2
SKCM	Src →	-0.224	-1.295	<.001	.009	3	2
SKCM	Bim →	-0.210	-1.440	.006	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by ADGRE1 expression — UCEC

Explore this box plot interactively →