ADGRE1

Across TCGA cell cohorts, ADGRE1 mutation is significantly associated with the mutation status of many other genes, with 2,615 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRE1-associated genes across cancer lineages are BICRA, B4GALNT3, and RUSC2. Each is linked with ADGRE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRE1-to-partner and partner-to-ADGRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BICRA grouped by ADGRE1-low versus ADGRE1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE1→partner) and Y-score (partner→ADGRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BICRA →	+3.113	+2.741	<.001	<.001	1	5
LARGE_INTESTINE	B4GALNT3 →	+2.415	+3.510	<.001	<.001	1	5
SKIN	RUSC2 →	+2.943	+2.362	.008	.008	1	4
BLOOD_Leukemia	YLPM1 →	+2.870	+3.347	.009	.009	1	4
SKIN	ZFHX3 →	+2.528	+2.440	.001	.001	1	4
SKIN	CDH18 →	+1.876	+2.181	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,615 associations by consensus.

BICRA by ADGRE1 expression — SKIN

Explore this box plot interactively →