ADGRD2

Across TCGA patient cohorts, ADGRD2 mutation is significantly associated with the RNA expression of many other genes, with 1,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRD2-associated genes across cancer lineages are TMEM242, TRIM16, and RAB11FIP1P1. Each is linked with ADGRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRD2-to-partner and partner-to-ADGRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM242 grouped by ADGRD2-low versus ADGRD2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRD2→partner) and Y-score (partner→ADGRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM242 →	+0.406	+2.553	.001	.009	3	2
COAD	TRIM16 →	+0.736	+3.321	<.001	.009	3	2
COAD	RAB11FIP1P1 →	-0.772	-3.558	.002	.003	3	2
UCEC	COX15 →	+0.389	+2.523	.001	<.001	3	2
UCEC	CENPU →	+0.724	+3.850	<.001	<.001	3	2
UCEC	TRIM36 →	+0.893	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,958 associations by consensus.

TMEM242 by ADGRD2 expression — COAD

Explore this box plot interactively →