ADGRD2

Across TCGA cell cohorts, ADGRD2 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRD2-associated genes across cancer lineages are ZPBP2, PPIAL4F, and EIF3E. Each is linked with ADGRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRD2-to-partner and partner-to-ADGRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZPBP2 grouped by ADGRD2-low versus ADGRD2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRD2→partner) and Y-score (partner→ADGRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZPBP2 →	+0.020	+5.169	<.001	.004	3	1
BONE	PPIAL4F →	+0.066	+5.169	<.001	.004	3	1
LARGE_INTESTINE	EIF3E →	+0.765	+3.212	.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1
LARGE_INTESTINE	CPO →	+0.104	+3.347	.001	.005	3	1
LARGE_INTESTINE	C8A →	+0.016	+2.514	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ZPBP2 by ADGRD2 expression — BONE

Explore this box plot interactively →