ADGRD1

Across TCGA patient cohorts, ADGRD1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ADGRD1-associated genes across cancer lineages are VHL, Src, and Cyclin-B1. Each is linked with ADGRD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRD1-to-partner and partner-to-ADGRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by ADGRD1-low versus ADGRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRD1→partner) and Y-score (partner→ADGRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.652	-1.662	.001	.010	3	4
UCEC	Src →	-0.155	-1.502	.013	.027	3	3
UCEC	Cyclin-B1 →	+0.650	+3.906	<.001	<.001	3	3
SKCM	Cyclin-E2 →	+0.134	+3.321	.030	.009	3	3
COAD	LKB1 →	+0.107	+2.000	.003	.029	3	3
COAD	Caspase-7-cleavedD198 →	+1.227	+3.338	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

VHL by ADGRD1 expression — UCEC

Explore this box plot interactively →