ADGRB2

Across TCGA patient cohorts, ADGRB2 mutation is significantly associated with the RNA expression of many other genes, with 4,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRB2-associated genes across cancer lineages are CDCA5, SRP19, and BUB3. Each is linked with ADGRB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRB2-to-partner and partner-to-ADGRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA5 grouped by ADGRB2-low versus ADGRB2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB2→partner) and Y-score (partner→ADGRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CDCA5 →	+0.493	+3.228	.008	.008	3	4
UCEC	SRP19 →	+0.363	+1.584	<.001	.002	3	4
COAD	BUB3 →	+0.367	+3.987	<.001	<.001	3	4
COAD	SKA1 →	+0.685	+3.335	<.001	<.001	3	4
COAD	H2AZ1 →	+0.430	+2.183	<.001	.001	3	4
UCEC	MAD2L1 →	+0.450	+1.584	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,590 associations by consensus.

CDCA5 by ADGRB2 expression — CESC

Explore this box plot interactively →