ADGRB2

Across TCGA patient cohorts, ADGRB2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRB2-associated genes across cancer lineages are GAPDH, PRDX1, and Caspase-7-cleavedD198. Each is linked with ADGRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRB2-to-partner and partner-to-ADGRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ADGRB2-low versus ADGRB2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB2→partner) and Y-score (partner→ADGRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.791	+3.321	<.001	.009	3	3
UCEC	PRDX1 →	+0.151	+1.347	.005	.005	3	3
COAD	Caspase-7-cleavedD198 →	+1.104	+2.186	<.001	.032	3	3
COAD	ASNS →	+0.566	+2.459	<.001	.018	3	3
LUSC	ACC1 →	+0.557	+2.331	.003	.019	3	2
UCEC	EGFR_pY1068 →	-0.147	-0.866	.025	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

GAPDH by ADGRB2 expression — COAD

Explore this box plot interactively →