ADGRB2

Across TCGA cell cohorts, ADGRB2 mutation is significantly associated with the RNA expression of many other genes, with 1,963 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADGRB2-associated genes across cancer lineages are RFK, WTAP, and PAXBP1. Each is linked with ADGRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRB2-to-partner and partner-to-ADGRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFK grouped by ADGRB2-low versus ADGRB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB2→partner) and Y-score (partner→ADGRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFK →	+0.443	+3.459	.008	.001	3	3
LARGE_INTESTINE	WTAP →	+0.395	+2.244	.006	.003	3	3
LARGE_INTESTINE	PAXBP1 →	+0.758	+2.158	<.001	.004	3	3
LARGE_INTESTINE	MSH4 →	+0.259	+2.242	<.001	.001	3	3
BLOOD_Leukemia	OR10K1 →	+0.247	+2.912	.004	<.001	3	3
BLOOD_Leukemia	PCGF3 →	+0.668	+3.614	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,963 associations by consensus.

RFK by ADGRB2 expression — LARGE_INTESTINE

Explore this box plot interactively →