Across TCGA patient cohorts, ADGRA1 mutation is significantly associated with the RNA expression of many other genes, with 2,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRA1-associated genes across cancer lineages are SNRPD3, MSANTD3, and OTX1. Each is linked with ADGRA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRA1-to-partner and partner-to-ADGRA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRA1→partner) and Y-score (partner→ADGRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNRPD3 →	+0.311	+2.510	.005	.009	3	4
UCEC	MSANTD3 →	+0.480	+2.148	.001	<.001	3	4
LUSC	OTX1 →	+1.179	+3.333	.001	.005	3	4
UCEC	GLUD1 →	+0.386	+2.947	.002	<.001	3	4
SKCM	IDH2-DT →	+0.083	+1.578	.005	.008	3	3
CESC	LINC02465 →	+0.102	+2.870	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,362 associations by consensus.

Exploration

ADGRA1 survival (RNA) · tumor vs normal (RNA) · all ADGRA1 data types