ADGB

Across TCGA patient cohorts, ADGB mutation is significantly associated with the RNA expression of many other genes, with 4,729 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGB-associated genes across cancer lineages are GSR, LONRF3, and CHAF1A. Each is linked with ADGB in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGB-to-partner and partner-to-ADGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSR grouped by ADGB-low versus ADGB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGB→partner) and Y-score (partner→ADGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GSR →	+0.519	+3.584	.002	.002	3	4
SCLC	LONRF3 →	+0.842	+2.844	.001	<.001	3	3
UCEC	CHAF1A →	+0.561	+1.741	<.001	<.001	3	3
COAD	B3GNT4 →	+0.416	+3.087	<.001	<.001	3	3
COAD	GEMIN4 →	+0.567	+4.169	<.001	<.001	3	3
UCEC	ITGAE →	+0.463	+1.506	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,729 associations by consensus.

GSR by ADGB expression — COAD

Explore this box plot interactively →