ADGB

Across TCGA patient cohorts, ADGB mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGB-associated genes across cancer lineages are FASN, eIF4E, and FOXO3a_pS318_S321. Each is linked with ADGB in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGB-to-partner and partner-to-ADGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ADGB-low versus ADGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGB→partner) and Y-score (partner→ADGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.227	+1.104	.013	.002	3	3
COAD	eIF4E →	+0.169	+3.182	.019	.009	3	2
UCEC	FOXO3a_pS318_S321 →	-0.074	-1.170	.010	.004	3	2
UCEC	MEK1 →	+0.418	+1.678	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.106	-1.427	.002	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.545	+1.319	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FASN by ADGB expression — UCEC

Explore this box plot interactively →