ADD3

Across TCGA patient cohorts, ADD3 mutation is significantly associated with the RNA expression of many other genes, with 3,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADD3-associated genes across cancer lineages are RNA5SP511, PSMB7P1, and RNA5SP237. Each is linked with ADD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADD3-to-partner and partner-to-ADD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP511 grouped by ADD3-low versus ADD3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD3→partner) and Y-score (partner→ADD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP511 →	+0.485	+6.059	<.001	<.001	3	3
SKCM	PSMB7P1 →	+0.028	+3.732	<.001	.001	3	3
CESC	RNA5SP237 →	+0.367	+5.669	<.001	.003	3	2
BLCA	RNU6ATAC29P →	+0.210	+3.623	.007	.004	3	2
KIRP	RNA5SP161 →	+0.281	+5.628	<.001	.004	3	2
KIRP	KLK9 →	+0.100	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,393 associations by consensus.

RNA5SP511 by ADD3 expression — LUSC

Explore this box plot interactively →