ADD3

Across TCGA patient cohorts, ADD3 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADD3-associated genes across cancer lineages are PCNA, EGFR_pY1068, and Notch1. Each is linked with ADD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADD3-to-partner and partner-to-ADD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADD3-low versus ADD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD3→partner) and Y-score (partner→ADD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.259	+1.947	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.253	-1.947	<.001	<.001	3	2
UCEC	Notch1 →	+0.153	+1.263	<.001	.019	3	2
UCEC	PDCD4 →	-0.447	-1.906	.001	.014	3	2
UCEC	Bax →	+0.147	+1.362	.046	.031	3	2
UCEC	Caspase-7-cleavedD198 →	+0.607	+1.867	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PCNA by ADD3 expression — UCEC

Explore this box plot interactively →