ADD3

Across TCGA cell cohorts, ADD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,055 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADD3-associated GO terms across cancer lineages are Barbed-end actin filament capping, Golgi vesicle transport, and Cytosolic transport. Each is linked with ADD3 in more than 12 cancer types. Because this analysis shows association rather than direction, both ADD3-to-partner and partner-to-ADD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Barbed-end actin filament capping grouped by ADD3-low versus ADD3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD3→partner) and Y-score (partner→ADD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Barbed-end actin filament capping →	+0.176	+1.210	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.074	+1.603	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.080	+1.310	.001	.001	3	11
SKIN	Glycerophospholipid biosynthetic process →	+0.031	+0.871	<.001	<.001	3	11
BREAST	Viral translational termination-reinitiation →	+0.079	+2.043	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Mitotic cytokinesis →	+0.082	+1.300	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

Barbed-end actin filament capping by ADD3 expression — PANCREAS

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