ADD3

Across TCGA cell cohorts, ADD3 mutation is significantly associated with the RNA expression of many other genes, with 1,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADD3-associated genes across cancer lineages are RPL3, DESI1, and METTL4. Each is linked with ADD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADD3-to-partner and partner-to-ADD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL3 grouped by ADD3-low versus ADD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD3→partner) and Y-score (partner→ADD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPL3 →	+0.397	+3.389	.009	.001	3	2
LARGE_INTESTINE	DESI1 →	+0.594	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	METTL4 →	+0.719	+2.652	<.001	.001	3	2
LARGE_INTESTINE	TBC1D12 →	+0.588	+2.850	.007	<.001	3	2
LARGE_INTESTINE	HSPA9 →	+0.506	+2.158	.003	.004	3	2
LARGE_INTESTINE	MXI1 →	+0.960	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,558 associations by consensus.

RPL3 by ADD3 expression — LARGE_INTESTINE

Explore this box plot interactively →