ADD3

Across TCGA cell cohorts, ADD3 mutation is significantly associated with the mutation status of many other genes, with 6,466 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADD3-associated genes across cancer lineages are ZNF462, PLXNA1, and TRAPPC9. Each is linked with ADD3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADD3-to-partner and partner-to-ADD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF462 grouped by ADD3-low versus ADD3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD3→partner) and Y-score (partner→ADD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF462 →	+4.502	+5.066	.007	.007	1	5
LARGE_INTESTINE	PLXNA1 →	+2.208	+2.208	<.001	<.001	1	5
OVARY	TRAPPC9 →	+4.977	+4.415	.007	.007	1	4
BLOOD_Leukemia	SLITRK5 →	+2.787	+3.962	<.001	<.001	1	4
LARGE_INTESTINE	MYO5B →	+2.371	+2.012	.001	.001	1	4
BLOOD_Leukemia	NEB →	+1.728	+2.954	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,466 associations by consensus.

ZNF462 by ADD3 expression — SOFT_TISSUE

Explore this box plot interactively →