ADD2

Across TCGA patient cohorts, ADD2 mutation is significantly associated with the RNA expression of many other genes, with 2,966 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADD2-associated genes across cancer lineages are SSX2B, EME1, and CX3CR1. Each is linked with ADD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADD2-to-partner and partner-to-ADD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX2B grouped by ADD2-low versus ADD2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD2→partner) and Y-score (partner→ADD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SSX2B →	+0.054	+4.211	<.001	.002	3	4
SKCM	EME1 →	+0.410	+1.622	<.001	.004	3	4
UCEC	CX3CR1 →	-0.492	-1.762	<.001	<.001	3	4
READ	RPL12P5 →	+0.213	+5.219	<.001	.006	3	3
LIHC	PYY3 →	+0.118	+5.914	<.001	<.001	3	3
UCEC	TAF9 →	+0.562	+2.237	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,966 associations by consensus.

SSX2B by ADD2 expression — LUSC

Explore this box plot interactively →