ADD2

Across TCGA cell cohorts, ADD2 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ADD2-associated genes across cancer lineages are GSTM5, TRIM60, and RHBG. Each is linked with ADD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADD2-to-partner and partner-to-ADD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTM5 grouped by ADD2-low versus ADD2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD2→partner) and Y-score (partner→ADD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GSTM5 →	+0.307	+3.334	<.001	<.001	3	2
SOFT_TISSUE	TRIM60 →	+0.283	+5.515	<.001	<.001	3	2
BLOOD_Lymphoma	RHBG →	+0.015	+2.514	<.001	.007	3	1
BLOOD_Lymphoma	GLOD5 →	+0.057	+3.321	<.001	<.001	3	1
BLOOD_Lymphoma	KY →	+0.180	+2.440	.003	.009	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.015	+2.867	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

GSTM5 by ADD2 expression — BLOOD_Lymphoma

Explore this box plot interactively →