ADD1

Across TCGA pan-cancer cohorts, ADD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ADD1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ADD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ADD1 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where ADD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.914	.015	78	view →
PDAC	DFS	Median	All	0.505	0.301	<.001	71	view →
LUAD	DFS	Median	All	0.941	0.428	<.001	24	view →
LSCC	DFS	Quartile	II,III,IV	0.573	0.933	.022	8	view →
CCRCC	OS	Quartile	All	0.925	0.741	.029	3	view →
HNSC	DFS	Quartile	III,IV	0.924	0.660	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ADD1–COAD (DFS)

Open the COAD breakdown →