ADD1

Across TCGA patient cohorts, ADD1 mutation is significantly associated with the RNA expression of many other genes, with 4,381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADD1-associated genes across cancer lineages are OR5T2, COX18, and HDGFL2. Each is linked with ADD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADD1-to-partner and partner-to-ADD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5T2 grouped by ADD1-low versus ADD1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD1→partner) and Y-score (partner→ADD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR5T2 →	+0.014	+4.357	<.001	.004	3	3
UCEC	COX18 →	+0.468	+2.099	<.001	<.001	3	3
UCEC	HDGFL2 →	+0.433	+2.684	<.001	<.001	3	3
SKCM	JPT1 →	+0.552	+3.487	.005	.002	3	3
UCEC	MIR6803 →	+0.105	+3.975	<.001	<.001	3	3
BLCA	ELMOD2 →	+0.473	+3.213	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,381 associations by consensus.

OR5T2 by ADD1 expression — CESC

Explore this box plot interactively →