ADD1

Across TCGA cell cohorts, ADD1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ADD1-associated genes across cancer lineages are REG3G, CRISP2, and KRT85. Each is linked with ADD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADD1-to-partner and partner-to-ADD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by ADD1-low versus ADD1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADD1→partner) and Y-score (partner→ADD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	REG3G →	+0.050	+3.906	<.001	.009	3	1
SOFT_TISSUE	CRISP2 →	+0.077	+3.297	.002	.008	3	1
SOFT_TISSUE	KRT85 →	+0.055	+3.384	<.001	.004	3	1
SOFT_TISSUE	ACP4 →	+0.042	+3.295	<.001	.006	3	1
SOFT_TISSUE	DEFB124 →	+0.245	+3.637	<.001	.002	3	1
SOFT_TISSUE	REC114 →	+0.040	+3.295	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

REG3G by ADD1 expression — BLOOD_Myeloma

Explore this box plot interactively →