ADCYAP1

Across TCGA patient cohorts, ADCYAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,144 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCYAP1-associated genes across cancer lineages are TRIM48, RN7SL83P, and IL9. Each is linked with ADCYAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCYAP1-to-partner and partner-to-ADCYAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM48 grouped by ADCYAP1-low versus ADCYAP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCYAP1→partner) and Y-score (partner→ADCYAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRIM48 →	+0.114	+4.807	<.001	.004	3	3
COAD	RN7SL83P →	+0.443	+4.807	<.001	.004	3	2
LUSC	IL9 →	+0.128	+3.466	.009	.002	3	2
UCEC	TRAJ30 →	+0.468	+2.368	.002	.003	3	2
UCEC	IGHD1-1 →	+0.590	+3.220	<.001	.005	3	2
UCEC	IGLV2-8 →	+1.531	+2.807	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,144 associations by consensus.

TRIM48 by ADCYAP1 expression — COAD

Explore this box plot interactively →