ADCYAP1

Across TCGA patient cohorts, ADCYAP1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCYAP1-associated genes across cancer lineages are PCNA, p27_pT157, and p62 Lck ligand. Each is linked with ADCYAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCYAP1-to-partner and partner-to-ADCYAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADCYAP1-low versus ADCYAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCYAP1→partner) and Y-score (partner→ADCYAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.291	+3.321	.007	.010	3	2
UCEC	p27_pT157 →	-0.069	-2.321	.017	.035	3	1
UCEC	p62 Lck ligand →	+0.471	+2.321	.003	.035	3	1
UCEC	Annexin-1 →	+0.529	+2.321	.045	.035	3	1
UCEC	AR →	-0.403	-2.321	.031	.035	3	1
UCEC	Tuberin →	+0.358	+3.179	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by ADCYAP1 expression — UCEC

Explore this box plot interactively →