ADCYAP1

Across TCGA cell cohorts, ADCYAP1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ADCYAP1-associated genes across cancer lineages are OR10W1, SCGB1C1, and SEMG1. Each is linked with ADCYAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCYAP1-to-partner and partner-to-ADCYAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by ADCYAP1-low versus ADCYAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCYAP1→partner) and Y-score (partner→ADCYAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.012	+4.977	.002	.007	3	1
LARGE_INTESTINE	SCGB1C1 →	+0.149	+4.977	<.001	.007	3	1
LUNG_SCLC	SEMG1 →	+0.015	+4.169	<.001	.001	3	1
LUNG_SCLC	CCDC172 →	+0.222	+3.523	.002	.008	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	OR8D1 →	+0.044	+4.070	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR10W1 by ADCYAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →