ADCY9

Across TCGA patient cohorts, ADCY9 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY9-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with ADCY9 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY9-to-partner and partner-to-ADCY9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ADCY9-low versus ADCY9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY9→partner) and Y-score (partner→ADCY9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.118	-2.124	.002	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.846	+1.710	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.340	+1.544	<.001	<.001	3	3
STAD	ERK2 →	+0.306	+3.169	.022	.018	3	2
STAD	FASN →	+0.382	+2.185	.034	.032	3	2
STAD	p70-S6K_pT389 →	-0.220	-3.000	.013	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

mTOR_pS2448 by ADCY9 expression — UCEC

Explore this box plot interactively →