ADCY9

Across TCGA cell cohorts, ADCY9 mutation is significantly associated with the RNA expression of many other genes, with 636 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY9-associated genes across cancer lineages are FREM3, GGA1, and HPS4. Each is linked with ADCY9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY9-to-partner and partner-to-ADCY9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FREM3 grouped by ADCY9-low versus ADCY9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY9→partner) and Y-score (partner→ADCY9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FREM3 →	+0.073	+2.054	.002	.003	3	2
LARGE_INTESTINE	GGA1 →	+0.610	+3.321	.002	.003	3	1
LARGE_INTESTINE	HPS4 →	+0.570	+2.714	.002	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.628	+3.829	<.001	<.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.906	+3.453	<.001	.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.678	+3.584	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 636 associations by consensus.

FREM3 by ADCY9 expression — LARGE_INTESTINE

Explore this box plot interactively →