ADCY7

Across TCGA patient cohorts, ADCY7 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY7-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and GAPDH. Each is linked with ADCY7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY7-to-partner and partner-to-ADCY7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ADCY7-low versus ADCY7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY7→partner) and Y-score (partner→ADCY7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.145	+1.331	.011	.043	3	3
UCEC	EGFR_pY1068 →	-0.249	-3.000	.003	<.001	3	2
UCEC	GAPDH →	+0.573	+2.222	.001	.009	3	2
UCEC	MSH2 →	-0.251	-3.558	.001	.002	3	2
UCEC	Rad50 →	-0.274	-1.514	<.001	.015	3	2
UCEC	Annexin-1 →	+0.489	+1.926	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Cyclin-E2 by ADCY7 expression — UCEC

Explore this box plot interactively →