ADCY6

Across TCGA pan-cancer cohorts, ADCY6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADCY6 data layer compared with 28 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADCY6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADCY6 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where ADCY6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.596	1.000	.007	20	view →
UCEC	OS	Quartile	III,IV	0.436	1.000	.043	4	view →
LSCC	DFS	Median	All	0.417	0.900	.003	3	view →
LUAD	OS	Quartile	III,IV	1.000	0.645	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ADCY6–HNSC (DFS)

Open the HNSC breakdown →