ADCY2

Across TCGA patient cohorts, ADCY2 protein abundance is significantly associated with the protein abundance of many other proteins, with 9,274 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADCY2-associated proteins across cancer lineages are SPTBN4, ACIN1_S410, and ACIN1_S657. Each is linked with ADCY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY2-to-partner and partner-to-ADCY2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADCY2 versus SPTBN4 in GBM, with a Pearson correlation of 0.62.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY2→partner) and Y-score (partner→ADCY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPTBN4 →	+0.439	+0.672	<.001	<.001	3	2
GBM	ACIN1_S410 →	-0.473	-0.801	<.001	<.001	3	1
GBM	ACIN1_S657 →	-0.632	-0.711	<.001	.001	3	1
GBM	ACIN1_S898 →	-0.299	-0.538	<.001	<.001	3	1
GBM	ACIN1_T1332 →	-0.735	-0.728	<.001	<.001	3	1
GBM	ACO2 →	+0.318	+0.485	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,274 associations by consensus.

ADCY2 vs SPTBN4 — GBM

Explore this scatter interactively →