ADCY2

Across TCGA patient cohorts, ADCY2 mutation is significantly associated with the RNA expression of many other genes, with 5,567 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY2-associated genes across cancer lineages are SEH1L, KIF22, and SNHG29. Each is linked with ADCY2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADCY2-to-partner and partner-to-ADCY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEH1L grouped by ADCY2-low versus ADCY2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY2→partner) and Y-score (partner→ADCY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SEH1L →	+0.462	+2.601	.007	.006	3	5
STAD	KIF22 →	+0.565	+3.717	.003	<.001	3	4
STAD	SNHG29 →	+0.808	+3.334	<.001	.005	3	4
LUSC	MRPS33 →	+0.376	+2.999	.009	.001	3	4
LUSC	GEMIN2 →	+0.405	+2.999	.007	.001	3	4
LUAD	CD207 →	-1.254	-1.938	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,567 associations by consensus.

SEH1L by ADCY2 expression — STAD

Explore this box plot interactively →