ADCY10

Across TCGA patient cohorts, ADCY10 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY10-associated genes across cancer lineages are Cyclin-B1, FoxM1, and JNK_pT183_Y185. Each is linked with ADCY10 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADCY10-to-partner and partner-to-ADCY10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ADCY10-low versus ADCY10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY10→partner) and Y-score (partner→ADCY10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.713	+1.874	<.001	<.001	3	4
BRCA	FoxM1 →	+0.394	+2.820	.043	.037	1	5
UCEC	JNK_pT183_Y185 →	-0.134	-1.514	.004	.014	3	3
UCEC	Ku80 →	+0.226	+1.691	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.307	-1.392	.014	.017	3	3
SKCM	PCNA →	+0.194	+1.295	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Cyclin-B1 by ADCY10 expression — UCEC

Explore this box plot interactively →