ADCY1

Across TCGA patient cohorts, ADCY1 protein abundance is significantly associated with the RNA expression of many other genes, with 971 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADCY1-associated genes across cancer lineages are MCM5, ZMAT5, and PVALB. Each is linked with ADCY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY1-to-partner and partner-to-ADCY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADCY1 versus MCM5 in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY1→partner) and Y-score (partner→ADCY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM5 →	-0.463	-0.276	<.001	<.001	3	1
GBM	ZMAT5 →	-0.220	-0.227	.003	.001	3	1
GBM	PVALB →	+0.815	+0.288	.001	<.001	3	1
GBM	KIAA0930 →	+0.375	+0.167	.001	.006	3	1
GBM	CPNE6 →	+0.692	+0.239	<.001	<.001	3	1
GBM	SGK2 →	+0.592	+0.236	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 971 associations by consensus.

ADCY1 vs MCM5 — GBM

Explore this scatter interactively →