ADCY1

Across TCGA patient cohorts, ADCY1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY1-associated genes across cancer lineages are eIF4E, PCNA, and Cyclin-E2. Each is linked with ADCY1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADCY1-to-partner and partner-to-ADCY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ADCY1-low versus ADCY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY1→partner) and Y-score (partner→ADCY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+3.920	.001	<.001	3	3
COAD	PCNA →	+0.348	+2.593	<.001	.006	3	3
UCEC	Cyclin-E2 →	+0.120	+1.273	.011	.007	3	3
STAD	Src →	-0.287	-3.321	.039	.010	3	2
STAD	Caspase-7-cleavedD198 →	+1.054	+3.321	.002	.010	1	4
SKCM	IRS1 →	+0.096	+1.152	.031	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

eIF4E by ADCY1 expression — UCEC

Explore this box plot interactively →