ADCY1

Across TCGA cell cohorts, ADCY1 mutation is significantly associated with the mutation status of many other genes, with 5,819 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY1-associated genes across cancer lineages are EVPL, CEP250, and FBN3. Each is linked with ADCY1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADCY1-to-partner and partner-to-ADCY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVPL grouped by ADCY1-low versus ADCY1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY1→partner) and Y-score (partner→ADCY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EVPL →	+4.263	+4.263	.001	.001	1	6
BLOOD_Leukemia	CEP250 →	+3.177	+3.531	<.001	<.001	1	6
STOMACH	FBN3 →	+4.584	+3.942	.002	.002	1	6
BLOOD_Leukemia	ATP2B2 →	+3.177	+3.531	<.001	<.001	1	6
LUNG_NSCLC_LUAD	HECTD4 →	+2.681	+3.807	<.001	<.001	1	6
BLOOD_Leukemia	RYR3 →	+1.662	+3.137	.002	.002	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,819 associations by consensus.

EVPL by ADCY1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →