ADCK2

Across TCGA patient cohorts, ADCK2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCK2-associated genes across cancer lineages are GAPDH, ACC1, and p62 Lck ligand. Each is linked with ADCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCK2-to-partner and partner-to-ADCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ADCK2-low versus ADCK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCK2→partner) and Y-score (partner→ADCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.576	+3.169	.011	.018	3	2
UCEC	ACC1 →	+0.386	+1.700	.012	.044	3	1
UCEC	p62 Lck ligand →	+0.331	+1.700	.016	.044	3	1
UCEC	Rad50 →	-0.380	-3.446	<.001	.005	3	1
UCEC	RAD51 →	+0.144	+1.700	.015	.044	3	1
UCEC	STAT3_pY705 →	-0.371	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by ADCK2 expression — UCEC

Explore this box plot interactively →