ADCK2

Across TCGA cell cohorts, ADCK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,624 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADCK2-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Regulation of isotype switching to IgG isotypes, and Fatty acid catabolic process. Each is linked with ADCK2 in more than 13 cancer types. Because this analysis shows association rather than direction, both ADCK2-to-partner and partner-to-ADCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by ADCK2-low versus ADCK2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCK2→partner) and Y-score (partner→ADCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.170	+1.102	<.001	<.001	3	14
LIVER	Regulation of isotype switching to IgG isotypes →	+0.155	+0.815	.008	.007	3	9
CNS	Fatty acid catabolic process →	+0.047	+0.462	<.001	.008	3	9
KIDNEY	Protein import into peroxisome matrix, receptor recycling →	+0.072	+0.905	.004	<.001	3	8
BREAST	Cajal body organization →	-0.116	-0.998	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Notch receptor processing →	+0.130	+0.795	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,624 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by ADCK2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →