ADCK2

Across TCGA cell cohorts, ADCK2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCK2-associated genes across cancer lineages are SLC5A5, KCNK17, and COX6A2. Each is linked with ADCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCK2-to-partner and partner-to-ADCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A5 grouped by ADCK2-low versus ADCK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCK2→partner) and Y-score (partner→ADCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC5A5 →	+0.378	+3.716	<.001	.003	3	1
LARGE_INTESTINE	KCNK17 →	+0.078	+3.906	<.001	.002	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	INSL5 →	+0.240	+3.626	<.001	.006	3	1
LARGE_INTESTINE	MRGPRX3 →	+0.355	+2.878	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SLC5A5 by ADCK2 expression — LARGE_INTESTINE

Explore this box plot interactively →