Across TCGA patient cohorts, ADAT2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAT2-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and INPP4B. Each is linked with ADAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAT2-to-partner and partner-to-ADAT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAT2→partner) and Y-score (partner→ADAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.162	-3.446	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.267	-3.169	<.001	.018	3	1
UCEC	INPP4B →	-0.345	-2.308	.033	.036	3	1
UCEC	ACVRL1 →	-0.149	-2.321	.029	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.247	-3.446	.003	.005	3	1
UCEC	JNK2 →	+0.275	+3.179	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

ADAT2 survival (RNA) · tumor vs normal (RNA) · all ADAT2 data types