ADAT1

Across TCGA pan-cancer cohorts, ADAT1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ADAT1 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ADAT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ADAT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

CESC, THCA, and OV are the cancer types where ADAT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	30	view →
THCA	DFS	Median	All	0.038	0.841	<.001	18	view →
OV	DFS	Median	All	0.266	0.541	.031	18	view →
UCEC	OS	Median	All	1.000	0.660	.025	10	view →
BLCA	DFS	Median	II,III,IV	0.915	0.498	.025	4	view →
LIHC	OS	Median	All	0.105	0.774	.002	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ADAT1–CESC (OS)

Open the CESC breakdown →