ADAT1

Across TCGA pan-cancer cohorts, ADAT1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADAT1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ADAT1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ADAT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, HNSC, and GBM are the cancer types where ADAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	1.000	0.685	.001	17	view →
HNSC	DFS	Median	III,IV	0.484	0.774	.010	11	view →
GBM	DFS	Quartile	All	0.490	0.860	.017	5	view →
PDAC	DFS	Quartile	All	0.678	0.826	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ADAT1–LUAD (OS)

Open the LUAD breakdown →