Across TCGA cell cohorts, ADARB1 mutation is significantly associated with the RNA expression of many other genes, with 240 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADARB1-associated genes across cancer lineages are KSR2, IQCF1, and ATG4C. Each is linked with ADARB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADARB1-to-partner and partner-to-ADARB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADARB1→partner) and Y-score (partner→ADARB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KSR2 →	+0.405	+3.502	.004	.001	3	2
BLOOD_Leukemia	IQCF1 →	+0.061	+4.354	<.001	<.001	3	2
LARGE_INTESTINE	ATG4C →	+0.677	+3.502	<.001	.001	3	2
LUNG_SCLC	TAS2R60 →	+0.940	+4.643	<.001	.004	3	1
LUNG_SCLC	OR8A1 →	+0.228	+4.044	.007	.009	3	1
SKIN	PRORY →	+0.641	+4.273	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

Exploration

ADARB1 survival (RNA) · tumor vs normal (RNA) · all ADARB1 data types