ADAR

Across TCGA patient cohorts, ADAR RNA expression is significantly associated with the protein abundance of many other proteins, with 11,483 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ADAR-associated proteins across cancer lineages are CMPK2, EIF2AK2, and IFIT3. Each is linked with ADAR in more than 7 cancer types. Because this analysis shows association rather than direction, both ADAR-to-partner and partner-to-ADAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAR versus CMPK2 in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAR→partner) and Y-score (partner→ADAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CMPK2 →	+1.020	+0.623	<.001	<.001	3	8
HNSC	EIF2AK2 →	+0.375	+0.582	<.001	.006	3	8
HNSC	IFIT3 →	+1.199	+0.478	<.001	<.001	3	8
LSCC	RPRD2 →	+0.270	+0.400	<.001	<.001	3	8
GBM	MX1 →	+1.265	+0.342	<.001	<.001	3	7
PDAC	OAS3 →	+0.598	+0.367	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,483 associations by consensus.

ADAR vs CMPK2 — HNSC

Explore this scatter interactively →