ADAR

Across TCGA patient cohorts, ADAR protein abundance is significantly associated with the RNA expression of many other genes, with 17,704 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ADAR-associated genes across cancer lineages are DDX58, DAP3, and CMPK2. Each is linked with ADAR in more than 8 cancer types. Because this analysis shows association rather than direction, both ADAR-to-partner and partner-to-ADAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAR versus DDX58 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAR→partner) and Y-score (partner→ADAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDX58 →	+1.150	+0.390	<.001	<.001	3	8
UCEC	DAP3 →	+0.832	+0.232	<.001	.002	3	8
HNSC	CMPK2 →	+1.167	+0.150	<.001	<.001	3	8
COAD	USP18 →	+1.089	+0.235	<.001	.001	3	8
LSCC	DARS2 →	+0.756	+0.345	<.001	<.001	3	8
GBM	CENPF →	+1.164	+0.204	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,704 associations by consensus.

ADAR vs DDX58 — OV

Explore this scatter interactively →