ADAR

Across TCGA patient cohorts, ADAR mutation is significantly associated with the RNA expression of many other genes, with 1,994 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAR-associated genes across cancer lineages are CCDC3, SLC25A4, and SKA1. Each is linked with ADAR in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAR-to-partner and partner-to-ADAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC3 grouped by ADAR-low versus ADAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAR→partner) and Y-score (partner→ADAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC3 →	-0.780	-2.169	<.001	<.001	3	3
UCEC	SLC25A4 →	+0.482	+1.903	<.001	<.001	3	3
UCEC	SKA1 →	+0.601	+2.928	<.001	<.001	3	3
UCEC	GLOD4 →	+0.381	+2.673	.001	<.001	3	3
UCEC	MCRIP2 →	+0.460	+2.337	<.001	<.001	3	3
UCEC	WDR62 →	+0.524	+2.831	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,994 associations by consensus.

CCDC3 by ADAR expression — UCEC

Explore this box plot interactively →