ADAR

Across TCGA patient cohorts, ADAR mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAR-associated genes across cancer lineages are Shc_pY317, Di-Ras3, and HER3_pY1289. Each is linked with ADAR in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAR-to-partner and partner-to-ADAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ADAR-low versus ADAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAR→partner) and Y-score (partner→ADAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.163	-2.415	.001	.003	3	3
COAD	Di-Ras3 →	-0.254	-2.991	.011	.036	3	2
UCEC	HER3_pY1289 →	+0.067	+2.341	.023	.019	3	2
UCEC	MEK1 →	+0.284	+2.070	.025	.001	3	2
UCEC	Rad50 →	-0.191	-2.070	.022	.001	3	2
UCEC	C-Raf →	+0.171	+2.000	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Shc_pY317 by ADAR expression — UCEC

Explore this box plot interactively →