ADAR

Across TCGA cell cohorts, ADAR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,220 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAR-associated GO terms across cancer lineages are Positive regulation of TORC2 signaling, mRNA 3'-end processing, and Epigenetic regulation of gene expression. Each is linked with ADAR in more than 17 cancer types. Because this analysis shows association rather than direction, both ADAR-to-partner and partner-to-ADAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of TORC2 signaling grouped by ADAR-low versus ADAR-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAR→partner) and Y-score (partner→ADAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of TORC2 signaling →	+0.133	+1.018	.001	<.001	3	18
LUNG_NSCLC_LUSC	mRNA 3'-end processing →	+0.087	+0.547	<.001	.001	3	16
PANCREAS	Epigenetic regulation of gene expression →	+0.056	+0.911	<.001	.002	3	16
STOMACH	Nucleic acid transport →	+0.108	+1.072	<.001	<.001	3	16
STOMACH	RNA transport →	+0.108	+1.072	<.001	<.001	3	16
STOMACH	RNA localization →	+0.106	+1.020	.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,220 associations by consensus.

Positive regulation of TORC2 signaling by ADAR expression — STOMACH

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