ADAR

Across TCGA cell cohorts, ADAR mutation is significantly associated with the RNA expression of many other genes, with 311 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAR-associated genes across cancer lineages are C12orf40, SFT2D3, and HES3. Each is linked with ADAR in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAR-to-partner and partner-to-ADAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by ADAR-low versus ADAR-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAR→partner) and Y-score (partner→ADAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.007	+2.859	.003	.008	3	2
BLOOD_Leukemia	SFT2D3 →	+0.484	+4.772	<.001	<.001	3	2
BONE	HES3 →	+0.053	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	GP9 →	+0.018	+3.777	<.001	<.001	3	1
LUNG_NSCLC_LUAD	NCBP2L →	+0.070	+3.860	.008	.001	3	1
LUNG_NSCLC_LUAD	USP17L19 →	+0.002	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

C12orf40 by ADAR expression — OVARY

Explore this box plot interactively →