Across TCGA patient cohorts, ADAP2 mutation is significantly associated with the RNA expression of many other genes, with 2,895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAP2-associated genes across cancer lineages are SLC7A11, SKA1, and PPP4R1. Each is linked with ADAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAP2-to-partner and partner-to-ADAP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAP2→partner) and Y-score (partner→ADAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC7A11 →	+0.824	+3.470	.002	.002	3	3
UCEC	SKA1 →	+0.879	+4.258	<.001	<.001	3	3
UCEC	PPP4R1 →	+0.399	+2.534	.006	.001	3	3
UCEC	DAD1 →	+0.401	+3.658	.005	.001	3	3
UCEC	UHRF1 →	+0.941	+3.180	<.001	<.001	3	2
UCEC	CCT5 →	+0.611	+3.513	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,895 associations by consensus.

Exploration

ADAP2 survival (RNA) · tumor vs normal (RNA) · all ADAP2 data types