Across TCGA patient cohorts, ADAMTSL5 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL5-associated genes across cancer lineages are PKC-b-II_pS660, S6_pS240_S244, and Caspase-7-cleavedD198. Each is linked with ADAMTSL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTSL5-to-partner and partner-to-ADAMTSL5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL5→partner) and Y-score (partner→ADAMTSL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	+0.349	+2.321	.011	.035	3	1
UCEC	S6_pS240_S244 →	+0.530	+2.820	.009	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.964	+2.827	.001	.035	3	1
UCEC	p90 RSK_pT359_S363 →	+0.201	+2.321	.048	.035	2	1
UCEC	14-3-3_beta →	-0.141	-3.446	.005	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

ADAMTSL5 survival (RNA) · tumor vs normal (RNA) · all ADAMTSL5 data types