Across TCGA cell cohorts, ADAMTSL5 mutation is significantly associated with the RNA expression of many other genes, with 161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTSL5-associated genes across cancer lineages are OR6J1, RWDD2A, and PRAMEF15. Each is linked with ADAMTSL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTSL5-to-partner and partner-to-ADAMTSL5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL5→partner) and Y-score (partner→ADAMTSL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR6J1 →	+0.038	+3.234	<.001	.008	3	2
LARGE_INTESTINE	RWDD2A →	+0.485	+3.451	.003	.002	3	2
OESOPHAGUS	PRAMEF15 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Leukemia	MYL7 →	+0.093	+4.661	<.001	<.001	3	1
BLOOD_Leukemia	PHOX2B →	+0.016	+4.365	.001	.002	3	1
BLOOD_Leukemia	CELA2A →	+0.303	+3.623	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

Exploration

ADAMTSL5 survival (RNA) · tumor vs normal (RNA) · all ADAMTSL5 data types